Utility of measuring (1,3)-β-d-glucan in cerebrospinal fluid for diagnosis of fungal central nervous system infection.
نویسندگان
چکیده
(1-3)-β-d-Glucan (BDG) from cerebrospinal fluid (CSF) is a promising marker for diagnostic and prognostic aid of central nervous system (CNS) fungal infection, but its relationship to serum values has not been studied. Herein, we detected BDG from CSF at levels 2-fold lower than those in serum in patients without evidence of fungal disease but 25-fold higher than those in in serum in noncryptococcal CNS fungal infections. CSF BDG may be a useful biomarker in the evaluation of fungal CNS disease.
منابع مشابه
(1-3)-β-D-glucan in cerebrospinal fluid is useful for the diagnosis of central nervous system fungal infections.
TO THE EDITOR—A definitive diagnosis of invasive fungal infection (IFI) remains difficult in immunocompromised hosts. Thus, fungal markers such as galacto-mannan (GM) or (1-3)-β-D-glucan (BG) are useful for the diagnosis of probable IFI in high risk patients [1]. Detection of GM in cerebrospinal fluid (CSF) has been studied and is now considered diagnostic for central nervous system (CNS) asper...
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عنوان ژورنال:
- Journal of clinical microbiology
دوره 53 1 شماره
صفحات -
تاریخ انتشار 2015